Genova Diagnostics:SIBO


Genova's SIBO Profiles are non-invasive breath tests which capture exhaled hydrogen (H2) and methane (CH4) gases following patient ingestion of a Lactulose ℞ solution to evaluate small intestinal bacterial overgrowth (SIBO) and intestinal methanogen overgrowth (IMO). 

Clinicians have the option of a 2 or 3-hour SIBO assessment. The 3-hour SIBO profile provides insight into gas levels over a longer time frame and is recommended for patients with slower gastrointestinal transit or constipation. Additionally, a flatline result in the third hour could indicate the presence of hydrogen sulfide gas.

SIBO is a common clinical condition characterised by excessive bacteria in the small intestine and can develop in a variety of patient populations. 

Symptoms and conditions commonly associated with SIBO include:2,4,5,6,7,8,9

  • Bloating/distension
  • Gas
  • Diarrhoea
  • Constipation
  • Abdominal pain
  • Dyspepsia
  • Irritable Bowel Syndrome (IBS)
  • Inflammatory Bowel Disease (IBD)
  • Coeliac Disease
  • Diabetes
  • Fibromyalgia
  • Rosacea
  • Parkinson's Disease
  • Obesity

Risk factors for development of SIBO include:4,6,7,10,11  

  • Intestinal motility disorders
  • Chronic pancreatitis
  • Abdominal structural/anatomic issues
  • Gastroenteritis
  • Immunocompromise
  • Decreased bacteriostatic digestive secretions (HCl, pancreatic enzymes, bile acids) such as with PPI use
  • Ileocecal valve dysfunction

If left untreated, SIBO can lead to complications such as malabsorption and intestinal permeability, or leaky gut.4,10

How it works

Consult Healthcare Provider
Your provider will discuss your symptoms and help decide which test is right for you. Many specimen collections can be completed from the privacy of your home.

Collect Samples
Use a calendar to plan for your collection. Follow instructions carefully and be sure to add important details about you and your specimens where indicated.

Ship to Lab
Ship specimens using the materials provided. Schedule time with your healthcare provider to review results and create a plan for your health.

Specimen: Breath