Genova Diagnostics:Adrenal Stress Profile


A Comprehensive Tool to Assess the HPA Axis - Stress Response and Resiliency

The Adrenal Stress Profile (ASP) provides an assessment of the Hypothalamic-Pituitary-Adrenal (HPA) axis using carefully timed salivary samples of the hormones cortisol and DHEA. Salivary testing is an easy, non-invasive option to measure unbound, biologically active parent hormone levels. The report offers an easy-to-interpret graphic which plots the results of the natural diurnal rhythm.

Which patients might benefit from HPA axis testing?

Daily hassles, chronic pain, blood sugar dysregulation, work stressors, and poor relationship quality can alter the HPA axis. Imbalances in adrenal hormones can have a wide range of negative consequences that can adversely impact a patient's overall quality of life.

HPA axis dysfunction is associated with many conditions including but not limited to:1,2,3,4,5,6,7,8,9

  • Hypertension
  • Cardiovascular disease
  • Gastrointestinal and immune dysregulation
  • Diabetes and metabolic syndrome
  • Depression
  • Chronic fatigue
  • Insomnia
  • Weight gain
  • Persistent pain
  • Neurodegenerative disease and cognitive decline

About the Adrenal Stress Profile

  • Four cortisol samples measured throughout the day give insight into the natural circadian diurnal cortisol rhythm, and help clinicians address specific daily stressors.
  • DHEA is measured once in the 7:00 AM - 9:00 AM sample.
  • Ratio of DHEA to cortisol is calculated to provide insight into anabolic/catabolic balance.

Optional Add-on:

  • Cortisol Awakening Response (CAR)
    • Two awakening samples to evaluate CAR.
    • CAR is a transient, immediate rise in cortisol upon awakening and is distinct from the diurnal rhythm. CAR reflects a person's ability to cope with anticipated challenges and their perception of control around chronic stress, providing insight into HPA axis resiliency.
  • Salivary secretory IgA (sIgA)
    • sIgA is secreted across mucosal membranes and regulates immune function
    • sIgA levels and immunity can be impacted by stress

Adrenal Stress Profile testing can reveal these HPA axis imbalances and provide direction for clinical intervention with targeted therapeutic treatments such as nutrient support and/or adaptogens, stress management, behavioral modification and lifestyle interventions.

How it works

Consult Healthcare Provider
Your provider will discuss your symptoms and help decide which test is right for you. Many specimen collections can be completed from the privacy of your home.

Collect Samples
Use a calendar to plan for your collection. Follow instructions carefully and be sure to add important details about you and your specimens where indicated.

Ship to Lab
Ship specimens using the materials provided. Schedule time with your healthcare provider to review results and create a plan for your health.